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, 9 (10), 387-94

Septins: Cytoskeletal Polymers or Signalling GTPases?


Septins: Cytoskeletal Polymers or Signalling GTPases?

C M Field et al. Trends Cell Biol.


Septins are a family of conserved proteins that have been implicated in a variety of cellular functions involving specialized regions of the cell cortex and changes in cell shape. The biochemistry and localization of septins suggest that they form a novel cytoskeletal system or that they function as scaffolds for the assembly of signalling complexes. This article discusses septin biochemistry and septin-interacting proteins, focusing on the missing link between the structure and biochemical properties of septin proteins, and on how they function at a molecular level in processes such as cytokinesis and yeast budding.

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