Septins: cytoskeletal polymers or signalling GTPases?

Trends Cell Biol. 1999 Oct;9(10):387-94. doi: 10.1016/s0962-8924(99)01632-3.


Septins are a family of conserved proteins that have been implicated in a variety of cellular functions involving specialized regions of the cell cortex and changes in cell shape. The biochemistry and localization of septins suggest that they form a novel cytoskeletal system or that they function as scaffolds for the assembly of signalling complexes. This article discusses septin biochemistry and septin-interacting proteins, focusing on the missing link between the structure and biochemical properties of septin proteins, and on how they function at a molecular level in processes such as cytokinesis and yeast budding.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / physiology*
  • Cytoskeletal Proteins / physiology*
  • GTP Phosphohydrolases / metabolism*
  • Mammals
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Signal Transduction*


  • Cell Cycle Proteins
  • Cytoskeletal Proteins
  • GTP Phosphohydrolases