Unravelling the kinetoplastid paraflagellar rod

Trends Cell Biol. 1999 Oct;9(10):409-13. doi: 10.1016/s0962-8924(99)01635-9.


Researchers who study human pathogens are often interested in unique and essential aspects of the biology of the pathogen. Recent progress has been made in understanding such a target in kinetoplastid parasites. The paraflagellar rod is a unique cytoskeletal structure that plays a key role in the life-cycle of these fascinating organisms. This review discusses the protein components and structure of the paraflagellar rod and its function in cell motility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Flagella / physiology*
  • Flagella / ultrastructure
  • Humans
  • Leishmania / pathogenicity
  • Leishmania / physiology*
  • Leishmania / ultrastructure
  • Movement
  • Proteins*
  • Protozoan Proteins / physiology*
  • Trypanosoma / pathogenicity
  • Trypanosoma / physiology*


  • Proteins
  • Protozoan Proteins
  • kinetoplast-associated protein, protozoan