Shaping excitation at glutamatergic synapses

Trends Neurosci. 1999 Oct;22(10):451-8. doi: 10.1016/s0166-2236(99)01445-9.


Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of glutamate transporters; and postsynaptic factors, including the types and locations of ionotropic glutamate receptors, their numbers, and the nature and locations of associated intracellular signalling systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Excitatory Postsynaptic Potentials / physiology
  • Glutamic Acid / physiology*
  • Humans
  • Neurons / chemistry
  • Neurons / physiology
  • Receptors, Glutamate / physiology*
  • Synapses / chemistry*
  • Synapses / physiology*


  • Receptors, Glutamate
  • Glutamic Acid