Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons

J Comput Neurosci. Jul-Aug 1999;7(1):5-15. doi: 10.1023/a:1008906225285.


Action potentials elicited in the axon actively back-propagate into the dendritic tree. During this process their amplitudes can be modulated by internal and external factors. We used a compartmental model of a hippocampal CA1 pyramidal neuron to illustrate how this modulation could depend on (1) the properties of an A-type K+ conductance that is expressed at high density in hippocampal dendrites and (2) the relative timing of synaptic activation. The simulations suggest that the time relationship between pre- and postsynaptic activity could help regulate the amplitude of back-propagating action potentials, especially in the distal portion of the dendritic tree.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / physiology*
  • Computer Simulation
  • Dendrites / physiology
  • Electric Conductivity
  • Hippocampus / cytology
  • Models, Neurological*
  • Potassium / metabolism*
  • Potassium Channels / physiology*
  • Pyramidal Cells / chemistry
  • Pyramidal Cells / physiology*
  • Pyramidal Cells / ultrastructure
  • Reaction Time / physiology
  • Synapses / physiology


  • Potassium Channels
  • Potassium