The neurological manifestations of Nipah virus encephalitis, a novel paramyxovirus

Ann Neurol. 1999 Sep;46(3):428-32.


A novel Hendra-like paramyxovirus named Nipah virus (NiV) was the cause of an outbreak among workers from one abattoir who had contact with pigs. Two patients had only respiratory symptoms, while 9 patients had encephalitis, 7 of whom are described in this report. Neurological involvement was diverse and multifocal, including aseptic meningitis, diffuse encephalitis, and focal brainstem involvement. Cerebellar signs were relatively common. Magnetic resonance imaging scans of the brain showed scattered lesions. IgM antibodies against Hendra virus (HeV) were present in the serum of all patients. Two patients recovered completely. Five had residual deficits 8 weeks later.

MeSH terms

  • Adult
  • Aged
  • Brain / pathology
  • Brain / virology
  • Encephalitis, Viral / pathology*
  • Humans
  • Magnetic Resonance Imaging
  • Malaysia
  • Male
  • Middle Aged
  • Nervous System Diseases / pathology*
  • Nervous System Diseases / virology*
  • Respirovirus Infections / pathology*