Rate of Switch From Depression Into Mania After Therapeutic Sleep Deprivation in Bipolar Depression

Psychiatry Res. 1999 Jun 30;86(3):267-70. doi: 10.1016/s0165-1781(99)00036-0.


Sleep deprivation is a potentially useful non-pharmacological treatment for depression. A relationship between sleep loss and the onset of mania has been reported, so it is possible that a switch from depression into mania after sleep deprivation might be expected in bipolar depressed patients who are treated with sleep deprivation. In a sample of 206 bipolar depressed treated with three cycles of sleep deprivation, alone or in combination with heterogeneous medications, we observed a 4.85% switch rate into mania and a 5.83% switch rate into hypomania. These percentages are comparable to those observed with antidepressant drug treatments.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use
  • Bipolar Disorder / complications
  • Bipolar Disorder / etiology*
  • Bipolar Disorder / therapy*
  • Combined Modality Therapy
  • Depression / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sleep Deprivation*
  • Treatment Outcome


  • Antidepressive Agents