Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study

J Appl Physiol (1985). 1999 Sep;87(3):1003-8. doi: 10.1152/jappl.1999.87.3.1003.


The aim of this study was to test the hypothesis that individual differences in the response of maximal O(2) uptake (VO(2max)) to a standardized training program are characterized by familial aggregation. A total of 481 sedentary adult Caucasians from 98 two-generation families was exercise trained for 20 wk and was tested for VO(2max) on a cycle ergometer twice before and twice after the training program. The mean increase in VO(2max) reached approximately 400 ml/min, but there was considerable heterogeneity in responsiveness, with some individuals experiencing little or no gain, whereas others gained >1.0 l/min. An ANOVA revealed that there was 2.5 times more variance between families than within families in the VO(2max) response variance. With the use of a model-fitting procedure, the most parsimonious models yielded a maximal heritability estimate of 47% for the VO(2max) response, which was adjusted for age and sex with a maternal transmission of 28% in one of the models. We conclude that the trainability of VO(2max) is highly familial and includes a significant genetic component.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging / physiology
  • Anaerobic Threshold / genetics*
  • Exercise / physiology*
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Models, Biological
  • Oxygen Consumption / genetics
  • Oxygen Consumption / physiology
  • Physical Endurance / genetics
  • Physical Endurance / physiology
  • Physical Fitness / physiology*
  • Sex Characteristics