Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Immunity. 1999 Aug;11(2):225-30. doi: 10.1016/s1074-7613(00)80097-7.


The activation and subsequent proliferation of peripheral T cells requires the engagement of the T cell and a cytokine receptor, typically the IL-2 or IL-4 receptors. Critical to understanding the regulation of peripheral T cells is the knowledge of the unique contributions of each receptor to full T cell activation and cell cycle progression. Mice deficient in Stat5a and Stat5b have demonstrated the essential role that these highly related proteins play in cell cycle progression following peripheral T cell activation. Here we demonstrate that activation of the Stat5 proteins by tyrosine phosphorylation is uniquely contributed by cytokine receptor signaling and specifically does not occur through the T cell receptor complex.

MeSH terms

  • Animals
  • CD3 Complex / immunology
  • Cytokines / pharmacology*
  • DNA / metabolism
  • DNA-Binding Proteins / metabolism*
  • Interleukin-2 / pharmacology
  • Interleukin-4 / pharmacology
  • Mice
  • Milk Proteins*
  • Phosphorylation
  • Receptors, Antigen, T-Cell / physiology
  • Receptors, Interleukin-2 / physiology
  • Receptors, Interleukin-4 / physiology
  • STAT5 Transcription Factor
  • T-Lymphocytes / physiology*
  • Trans-Activators / metabolism*


  • CD3 Complex
  • Cytokines
  • DNA-Binding Proteins
  • Interleukin-2
  • Milk Proteins
  • Receptors, Antigen, T-Cell
  • Receptors, Interleukin-2
  • Receptors, Interleukin-4
  • STAT5 Transcription Factor
  • Stat5a protein, mouse
  • Stat5b protein, mouse
  • Trans-Activators
  • Interleukin-4
  • DNA