Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)

Genomics. 1999 Sep 1;60(2):179-87. doi: 10.1006/geno.1999.5909.


The integrins are a large family of cell adhesion molecules consisting of noncovalently associated alphabeta heterodimers. We have cloned and sequenced the cDNA of a novel human integrin alpha-subunit, designated alpha11. The alpha11 cDNA encodes a mature protein with a large 1120-residue extracellular domain that contains an I-domain of 207 residues and is linked by a transmembrane domain to a short cytoplasmic domain of 24 amino acids. The deduced alpha11 protein shows the typical structural features of integrin alpha-subunits and is similar to a distinct group of alpha-subunits from collagen-binding integrins. However, it differs from most integrin alpha-chains by an incompletely preserved cytoplasmic GFFKR motif. The human ITGA11 gene was localized to bands q22.3-q23 on chromosome 15, and its transcripts were found in a variety of tissues, but predominantly in bone, cartilage, cardiac muscle, and skeletal muscle. Expression of a 5.5-kb alpha11 mRNA was detectable in small intestine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15 / genetics
  • Cloning, Molecular
  • DNA Primers / genetics
  • DNA, Complementary / genetics
  • DNA, Complementary / isolation & purification
  • Female
  • Humans
  • Integrin alpha Chains*
  • Integrins / chemistry
  • Integrins / genetics*
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Collagen
  • Tissue Distribution


  • DNA Primers
  • DNA, Complementary
  • ITGA11 protein, human
  • Integrin alpha Chains
  • Integrins
  • RNA, Messenger
  • Receptors, Collagen

Associated data

  • GENBANK/AF109681