Abstract
Diffusible and substrate-bound cues can guide axonal pathway choice via attractive and repulsive signals. A number of families of signalling molecules have been identified, including netrins and their receptors, semaphorins, neuropilins, Eph receptor tyrosine kinases, ephrins and CAMs. Many of these signalling molecules can have a dual role, functioning either as attractants or as repellents. Direction of growth cone extension requires reorganization of the cytoskeleton, which may be directed by the Rho family of GTPases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Axons / physiology
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Humans
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Nerve Growth Factors / physiology
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Nerve Tissue Proteins / physiology
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Nervous System / growth & development*
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Nervous System Physiological Phenomena
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Netrin Receptors
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Neural Cell Adhesion Molecules / physiology
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Neural Pathways / growth & development
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Receptor Protein-Tyrosine Kinases / physiology
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Receptor, EphA1
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Receptors, Cell Surface / physiology
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Signal Transduction
Substances
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Nerve Growth Factors
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Nerve Tissue Proteins
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Netrin Receptors
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Neural Cell Adhesion Molecules
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Receptors, Cell Surface
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Receptor Protein-Tyrosine Kinases
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Receptor, EphA1