Mitochondria in the life and death of neurons

Essays Biochem. 1998;33:43-52. doi: 10.1042/bse0330043.

Abstract

A prolonged decrease in ATP levels underlies a number of neurodegenerative disorders. Defects in oxidative phosphorylation are associated with a number of neurodegenerative disorders. Mitochondria also play an important role in mediating the initiation of apoptosis.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Animals
  • Apoptosis / physiology
  • Energy Metabolism
  • Humans
  • Mitochondria / metabolism*
  • Mitochondrial Myopathies / etiology
  • Models, Neurological
  • Neurodegenerative Diseases / etiology
  • Neurons / cytology*
  • Neurons / metabolism*
  • Parkinson Disease / etiology
  • Receptors, N-Methyl-D-Aspartate / metabolism

Substances

  • Receptors, N-Methyl-D-Aspartate