Long-term potentiation--a decade of progress?

Science. 1999 Sep 17;285(5435):1870-4. doi: 10.1126/science.285.5435.1870.

Abstract

Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Signaling
  • Hippocampus / physiology*
  • Humans
  • Long-Term Potentiation / physiology*
  • Models, Neurological
  • Protein Kinases / metabolism
  • Pyramidal Cells / physiology
  • Receptors, AMPA / metabolism
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Synapses / physiology*
  • Synaptic Transmission / physiology

Substances

  • Receptors, AMPA
  • Receptors, N-Methyl-D-Aspartate
  • Protein Kinases