The role of the podocyte in glomerulosclerosis

Curr Opin Nephrol Hypertens. 1999 Jul;8(4):489-97. doi: 10.1097/00041552-199907000-00014.


Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The 'classic' lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane. The recently described 'collapsing' variant, in contrast, has an apparent excess of extracapillary cells, which may represent dedifferentiated, 'dysregulated' podocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Epithelium / pathology
  • Epithelium / physiopathology
  • Glomerulosclerosis, Focal Segmental / pathology*
  • Glomerulosclerosis, Focal Segmental / physiopathology*
  • Humans
  • Kidney Glomerulus / pathology*
  • Kidney Glomerulus / physiopathology*