The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory

Immunol Res. 1999;19(2-3):107-18. doi: 10.1007/BF02786480.


The role of self-antigen recognition in the development of T and B cells of the adaptive immune system has been studied in several different ways. We have shown that CD4 T cells are selected on self-peptide:self-MHC class II ligands, and in the periphery, they are sustained by contact with the same or similar ligands. We have also observed that B cells are positively selected on unknown and presumed self-ligands. We have used this information to explore autoimmune diseases as well. Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantigens / immunology*
  • Autoimmune Diseases / immunology
  • Disease Models, Animal
  • Humans
  • Immunity, Innate
  • Major Histocompatibility Complex
  • Receptors, Antigen, B-Cell / immunology*
  • Receptors, Antigen, T-Cell / immunology*


  • Autoantigens
  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell