Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus)

Behav Neurosci. 1999 Aug;113(4):804-15. doi: 10.1037//0735-7044.113.4.804.

Abstract

These studies examined the neurochemistry and neuroanatomy of the serotonin (5-HT) system innervating the anterior hypothalamus (AH) and the interaction of 5-HT receptor agonists with arginine vasopressin (AVP) in the regulation of offensive aggression in golden hamsters. Because specific 5-HT1A, 5-HT1B, and AVP V1A binding sites were observed within the AH by in vitro autoradiography, the hamsters were tested for offensive aggression after microinjections of AVP in combination with either the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetraline (DPAT) or the 5-HT1B agonist CGS-12066A (CGS) directly within the AH. Though treatment with DPAT resulted in a dose-dependent inhibition of AVP-facilitated offensive aggression, CGS was ineffective. In addition, a retrograde tracer was injected within the AH to localize the distribution of 5-HT neurons projecting to the area. Retrogradely labeled 5-HT neurons were found within the dorsal, median, and caudal linear raphe nuclei and are suspected to inhibit AVP-facilitated offensive aggression by an activation of 5-HT1A receptors in the AH.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / administration & dosage
  • Aggression*
  • Animals
  • Arginine Vasopressin / administration & dosage
  • Behavior, Animal*
  • Cricetinae
  • Hypothalamus, Anterior / anatomy & histology*
  • Hypothalamus, Anterior / metabolism*
  • Male
  • Mesocricetus
  • Neural Pathways / anatomy & histology
  • Neural Pathways / metabolism
  • Neurotransmitter Agents / administration & dosage*
  • Quinoxalines / administration & dosage
  • Raphe Nuclei / anatomy & histology
  • Raphe Nuclei / metabolism
  • Receptors, Serotonin / metabolism
  • Serotonin / metabolism*
  • Serotonin Receptor Agonists / administration & dosage*

Substances

  • Neurotransmitter Agents
  • Quinoxalines
  • Receptors, Serotonin
  • Serotonin Receptor Agonists
  • CGS 12066B
  • Arginine Vasopressin
  • Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin