Compartmentalized Expression of Zebrafish ten-m3 and ten-m4, Homologues of the Drosophila ten(m)/odd Oz Gene, in the Central Nervous System

Mech Dev. 1999 Sep;87(1-2):223-7. doi: 10.1016/s0925-4773(99)00155-0.

Abstract

Zebrafish ten-m3 and ten-m4 encode proteins highly similar to the product of Drosophila pair-rule gene ten(m)/odd Oz (odz). Their products contain eight epidermal growth factor (EGF)-like repeats that resemble mostly those of the extracellular matrix molecule tenascin. During segmentation period, ten-m3 is expressed in the somites, notochord, pharyngeal arches, and the brain, while expression of ten-m4 is mainly restricted to the brain. In the developing brain, ten-m3 and ten-m4 expression delineates several compartments. Interestingly, ten-m3 and ten-m4 show expression patterns complementary to each other in the developing forebrain and midbrain along both rostrocaudal and dorsoventral axes, depending on developmental stages and locations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA, Complementary / analysis
  • Drosophila
  • Drosophila Proteins*
  • Gene Expression*
  • In Situ Hybridization
  • Mesencephalon / embryology
  • Mesencephalon / metabolism*
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Rhombencephalon / embryology
  • Rhombencephalon / metabolism*
  • Sequence Homology, Amino Acid
  • Tenascin / metabolism*
  • Time Factors
  • Zebrafish
  • Zebrafish Proteins*

Substances

  • DNA, Complementary
  • Drosophila Proteins
  • Nerve Tissue Proteins
  • Ten-m protein, Drosophila
  • Tenascin
  • Zebrafish Proteins
  • tenm3 protein, zebrafish
  • tenm4 protein, zebrafish

Associated data

  • GENBANK/AB026979
  • GENBANK/AB026980