The pathogeny of cutaneous ulcers is complex. The role of a critical bacterial contamination is controversial. The use of topical antibiotics is unwise, and that of antiseptics is still a matter of debate. Some authors contend that antiseptics mitigate wound healing through a toxic effect upon keratinocytes and fibroblasts. Other researchers bring forward sound arguments to support the concept of beneficial cytotoxicity of antiseptics in the treatment of chronic cutaneous ulcers.