Effect of selective versus nonselective beta blockade on QT dispersion in patients with nonischemic dilated cardiomyopathy

Am J Cardiol. 1999 Aug 1;84(3):350-4, A9. doi: 10.1016/s0002-9149(99)00294-5.

Abstract

We retrospectively examined the electrocardiograms in all of our patients with nonischemic dilated cardiomyopathy and normal sinus rhythm before and after at least 3 months of metoprolol (n = 12), bucindolol (n = 8), carvedilol (n = 6), or no beta blocker (n = 9). Both beta1-selective and nonselective beta-adrenergic blockade reduced QTc dispersion equally in patients with dilated cardiomyopathy.

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Adult
  • Aged
  • Carbazoles / pharmacology
  • Cardiomyopathy, Dilated / drug therapy*
  • Cardiomyopathy, Dilated / etiology
  • Cardiomyopathy, Dilated / mortality
  • Cardiomyopathy, Dilated / physiopathology
  • Carvedilol
  • Death, Sudden, Cardiac / prevention & control
  • Electrocardiography / drug effects
  • Female
  • Heart Conduction System / drug effects*
  • Humans
  • Male
  • Metoprolol / pharmacology
  • Middle Aged
  • Propanolamines / pharmacology
  • Retrospective Studies
  • Stroke Volume / drug effects
  • Treatment Outcome

Substances

  • Adrenergic beta-Antagonists
  • Carbazoles
  • Propanolamines
  • Carvedilol
  • bucindolol
  • Metoprolol