Effect of dexamethasone on bovine airway smooth muscle cell proliferation

J Asthma. 1999 Sep;36(6):519-25. doi: 10.3109/02770909909054558.


Airway smooth muscle proliferation is a key component of airway wall remodelling that occurs as a consequence of inflammation in asthma. Studies were conducted to examine the effect of dexamethasone on airway smooth muscle cell (ASMC) proliferation in vitro. Dexamethasone (25-250 nM) significantly inhibited DNA synthesis and cell division induced by beta-hexosaminidase A (Hex A, 50 nM) in bovine ASMC. The inhibitory effect of dexamethasone on DNA synthesis was variable depending on the growth factors: significant effect was observed on Hex A and insulin; no significant effect was observed on epidermal growth factor and fetal bovine serum.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Asthma / pathology
  • Cattle
  • Cell Division / drug effects*
  • Cells, Cultured
  • DNA Replication / drug effects*
  • Dexamethasone / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Hyperplasia
  • Muscle, Smooth / drug effects*
  • Trachea / drug effects
  • Trachea / pathology


  • Anti-Inflammatory Agents
  • Dexamethasone