Gli proteins and Hedgehog signaling: development and cancer

Trends Genet. 1999 Oct;15(10):418-25. doi: 10.1016/s0168-9525(99)01840-5.


A surprising number of apparently unrelated human diseases, including familial and sporadic cancers and a number of syndromes and malformations, seem to be associated with abnormal function of the Hedgehog (Hh) signaling pathway. Zinc-finger transcription factors of the Gli family play critical roles in the mediation and interpretation of Hh signals. Elucidating how Gli proteins work will enable us to further our knowledge of how cells proliferate, differentiate or survive in response to Hh signals, as well as to design rational therapies for these Hh-signaling related diseases (HSDs).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drosophila Proteins*
  • Hedgehog Proteins
  • Humans
  • Insect Proteins / metabolism*
  • Neoplasms / metabolism*
  • Oncogene Proteins / metabolism*
  • Oncogene Proteins / physiology
  • Signal Transduction*
  • Trans-Activators
  • Transcription Factors / metabolism*
  • Transcription Factors / physiology
  • Zinc Finger Protein GLI1


  • Drosophila Proteins
  • Hedgehog Proteins
  • Insect Proteins
  • Oncogene Proteins
  • Trans-Activators
  • Transcription Factors
  • Zinc Finger Protein GLI1
  • hh protein, Drosophila