The mar regulon: multiple resistance to antibiotics and other toxic chemicals

Trends Microbiol. 1999 Oct;7(10):410-3. doi: 10.1016/s0966-842x(99)01589-9.


The chromosomal multiple antibiotic resistance (mar) locus of Escherichia coli and other members of the Enterobacteriaceae controls resistance to multiple, structurally unrelated compounds including antibiotics, household disinfectants, organic solvents and other toxic chemicals. The Mar phenotype is induced following exposure to a variety of chemicals with aromatic rings.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Disinfectants / pharmacology*
  • Drug Resistance, Microbial / genetics
  • Drug Resistance, Multiple / genetics*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Humans
  • Regulon*
  • Solvents / pharmacology


  • Anti-Bacterial Agents
  • Disinfectants
  • Solvents