The mar regulon: multiple resistance to antibiotics and other toxic chemicals

M N Alekshun; S B Levy

doi:10.1016/s0966-842x(99)01589-9

The mar regulon: multiple resistance to antibiotics and other toxic chemicals

Trends Microbiol. 1999 Oct;7(10):410-3. doi: 10.1016/s0966-842x(99)01589-9.

Authors

M N Alekshun¹, S B Levy

Affiliation

¹ Center for Adaptation Genetics and Drug Resistance, Dept of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.

PMID: 10498949
DOI: 10.1016/s0966-842x(99)01589-9

Abstract

The chromosomal multiple antibiotic resistance (mar) locus of Escherichia coli and other members of the Enterobacteriaceae controls resistance to multiple, structurally unrelated compounds including antibiotics, household disinfectants, organic solvents and other toxic chemicals. The Mar phenotype is induced following exposure to a variety of chemicals with aromatic rings.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Anti-Bacterial Agents / pharmacology*
Disinfectants / pharmacology*
Drug Resistance, Microbial / genetics
Drug Resistance, Multiple / genetics*
Escherichia coli / drug effects*
Escherichia coli / genetics
Humans
Regulon*
Solvents / pharmacology

Substances

Anti-Bacterial Agents
Disinfectants
Solvents

Grants and funding

GM 51661/GM/NIGMS NIH HHS/United States