Regulatory T cells and inflammatory bowel disease

Immunol Today. 1999 Oct;20(10):442-5. doi: 10.1016/s0167-5699(99)01510-8.


Recent studies have identified interleukin 10 as a differentiation factor for a novel subset of immune suppressive regulatory T cells. Here, Hervé Groux and Fiona Powrie discuss the role that these cells play in the regulation of immune responses to enteric antigens and suggest that a deficiency in these cells might be involved in the pathogenesis of inflammatory bowel disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Humans
  • Inflammatory Bowel Diseases / immunology*
  • Inflammatory Bowel Diseases / pathology
  • Inflammatory Bowel Diseases / therapy
  • Interleukin-10 / immunology
  • Mice
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / pathology


  • Interleukin-10