Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide

Intensive Care Med. 1999 Sep;25(9):911-9. doi: 10.1007/s001340050982.


Objective: To determine whether inhalation of nitric oxide (INO) can increase the frequency of reversal of acute lung injury (ALI) in nitric oxide (NO) responders.

Design: Prospective, open, randomised, multicentre, parallel group phase III trial.

Setting: General ICUs in 43 university and regional hospitals in Europe.

Patients: Two hundred and sixty-eight adult patients with early ALI.

Interventions: NO responders were patients whose PaO(2) increased by more than 20 % when receiving 0, 2, 10 and 40 ppm of INO for 10 min within 96 h of study entry. Responders were randomly allocated to conventional treatment with or without INO. INO, 1-40 ppm, was given at the lowest effective dose for up to 30 days or until an end point was reached. The primary end point was reversal of ALI. Clinical outcome parameters and safety were assessed in all patients.

Results: Two hundred and sixty-eight patients were recruited, of which 180 were randomised NO responders. Frequency of reversal of ALI was no different in INO patients (61 %) and controls (54 %; p > 0.2). Development of severe respiratory failure was lower in the INO (2.2 % ) than controls (10.3 %; p < 0.05). The mortality at 30 days was 44 % for INO patients, 40 % for control patients (p > 0.2 vs INO) and 45 % in non-responders.

Conclusions: Improvement of oxygenation by INO did not increase the frequency of reversal of ALI. Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Adult
  • Aged
  • Dose-Response Relationship, Drug
  • Europe / epidemiology
  • Female
  • Humans
  • Male
  • Methemoglobinemia / blood
  • Middle Aged
  • Nitric Oxide / administration & dosage*
  • Nitric Oxide / adverse effects
  • Prospective Studies
  • Respiratory Distress Syndrome / blood
  • Respiratory Distress Syndrome / drug therapy*
  • Respiratory Distress Syndrome / mortality
  • Time Factors
  • Vasodilator Agents / administration & dosage*
  • Vasodilator Agents / adverse effects


  • Vasodilator Agents
  • Nitric Oxide