Understanding CNS remyelination: clues from developmental and regeneration biology

J Neurosci Res. 1999 Oct 15;58(2):207-13.


A guiding principle in remyelination research has been to seek clues to its nature in developmental studies on myelination. This "recapitulation hypothesis" argues that the regenerative response involves rerunning much the same programme as occurs during the developmental process. Here we examine the extent to which current evidence supports this hypothesis and whether this is a useful conceptual framework within which to study remyelination and suggest that an equally fruitful approach is to look to regenerative processes in other tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology
  • Central Nervous System / physiology*
  • Growth Substances / physiology
  • Myelin Sheath / physiology*
  • Nerve Regeneration / physiology*
  • Oligodendroglia / physiology
  • Stem Cells / physiology


  • Growth Substances