Vascular endothelial (VE)-cadherin: only an intercellular glue?

Exp Cell Res. 1999 Oct 10;252(1):13-9. doi: 10.1006/excr.1999.4601.


Data collected during the past years indicate that AJ- and more specifically VE-cadherin play an important role in endothelial cell biology. VE-cadherin may transfer information intracellularly through interaction with a complex network of cytoskeletal and signaling molecules. Expression of VE-cadherin is required for the control of vascular permeability and vascular integrity. In addition, the molecule may exert a morphogenetic role modulating the capacity of endothelial cells to organize into tubular-like structures. VE-cadherin presents many structural and sequence homologies to the other members of the family and apparently binds to the same intracellular molecules. However, remarkably, VE-cadherin may transfer specific signals to endothelial cells to modulate their functional reactivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Cadherins / genetics
  • Cadherins / physiology*
  • Capillary Permeability
  • Cell Adhesion
  • Endothelium, Vascular / physiology*
  • Homeostasis
  • Humans
  • Signal Transduction


  • Antigens, CD
  • Cadherins
  • cadherin 5