Tissue-specific consequences of the anti-adenoviral immune response: implications for cardiac transplants

Nat Med. 1999 Oct;5(10):1143-9. doi: 10.1038/13467.


The immune response to adenoviral vectors can induce inflammation and loss of transgene expression in transfected tissues. This would limit the use of adenovirus-mediated gene transfer in disease states in which long-term gene expression is required. While studying the effect of the anti-adenoviral immune response in transplantation, we found that transgene expression persisted in cardiac isografts transfected with an adenovirus encoding beta-galactosidase. Transfected grafts remained free of inflammation, despite the presence of an immune response to the vector. Thus, adenovirus-mediated gene transfer may have therapeutic value in cardiac transplantation and heart diseases. Furthermore, immunological limitations of adenoviral vectors for gene therapy are not universal for all tissue types.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / immunology*
  • Animals
  • Female
  • Gene Transfer Techniques*
  • Genetic Vectors / immunology*
  • Heart Transplantation / adverse effects
  • Heart Transplantation / immunology*
  • Infusions, Intravenous
  • Mice
  • Mice, Inbred C57BL
  • Transgenes
  • Transplantation, Isogeneic
  • beta-Galactosidase / genetics


  • beta-Galactosidase