Effect of blood flow rate on thrombogenesis in a rabbit extracorporeal circulation model

ASAIO J. 1999 Sep-Oct;45(5):478-81. doi: 10.1097/00002480-199909000-00021.


Blood flow is believed to affect the thrombogenicity of extracorporeal circulation (ECC). The purpose of this study was to look at the relationship between blood flow and thrombogenicity in a rabbit model of ECC. Rabbits were anesthetized and systematically heparinized. Bilateral jugular cannulation was performed, and the animals were placed on venovenous ECC. The circuits were composed of 1 m of 1/4 inch size surgical grade polyvinylchloride (PVC) tubing. ECC was maintained for 4 hours. Three experimental groups were studied: a high flow group (n=7; flow rate: 30 ml/min/Kg), low flow group (n=7; flow rate: 10 ml/mg/Kg), and no ECC group (n=7). Platelet count, fibrinogen concentration, PaO2/FiO2, and postmortem findings were evaluated. Platelet consumption was higher with high flow, and fibrinogen consumption was higher with low flow.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Flow Velocity
  • Extracorporeal Circulation*
  • Fibrinogen / metabolism
  • Platelet Activation
  • Platelet Adhesiveness
  • Rabbits
  • Thrombosis / etiology*


  • Fibrinogen