Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells

Kidney Int. 1999 Oct;56(4):1254-7. doi: 10.1046/j.1523-1755.1999.00696.x.

Abstract

We studied the effects of cyclosporine A (CsA) on the proliferation of LLC-PK1 proximal tubule epithelial cells. DNA damage was found to be an early event in CsA nephrotoxicity and could be a sensitive indicator of CsA injury in renal epithelial cells. Cell cycle arrest induced by CsA was coincident with elevated p53 levels. It is possible that trans-activating p21 may mediate the halting of the cell cycle through the CsA-induced accumulation of p53.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / drug effects
  • Cell Death / drug effects*
  • Cyclosporine / pharmacology*
  • Epithelial Cells / cytology*
  • Epithelial Cells / drug effects
  • Immunosuppressive Agents / pharmacology*
  • Kidney / cytology*
  • LLC-PK1 Cells / cytology
  • LLC-PK1 Cells / drug effects
  • Swine

Substances

  • Immunosuppressive Agents
  • Cyclosporine