Lipomatous hemangiopericytoma: a morphologically distinct soft tissue tumor

Arch Pathol Lab Med. 1999 Oct;123(10):941-5. doi: 10.5858/1999-123-0941-LH.


Hemangiopericytoma of soft tissue is a controversial pathologic entity. The relative nonspecificity of the characteristic branching capillary pattern and cytologic features of the constituent cells, in addition to the lack of a distinct immunohistochemical staining profile, has resulted in uncertainty and a lack of consensus regarding this subgroup of tumors. Notwithstanding the doubt surrounding this entity, a morphologically unique variant, designated lipomatous hemangiopericytoma, was reported in 1995. To our knowledge, there have been no further reports of these tumors since the original description. We describe a lipomatous hemangiopericytoma that arose within the thigh of a 41-year-old woman. The tumor presented as a slowly enlarging, minimally tender, pulsatile mass. The tumor was completely excised and was found to be composed of an admixture of typical hemangiopericytoma and predominantly mature adipose tissue. Unlike previous descriptions of this entity, the current example exhibited a full range of adipocyte differentiation, including many multivacuolated adipocytes of variable size with characteristic nuclear scalloping (lipoblast-like cells). The mitotic count was less than 2 per 10 high-power fields examined. The clinical course has been benign during the short follow-up period. We discuss the pathologic features, including the immunohistochemical staining profile and ultrastructural appearance of this distinctive tumor, and briefly discuss the relationship between hemangiopericytoma and solitary fibrous tumor of soft tissue, a neoplasm with many clinical and pathologic similarities.

MeSH terms

  • Adult
  • Biomarkers, Tumor
  • Female
  • Hemangiopericytoma / chemistry
  • Hemangiopericytoma / diagnostic imaging
  • Hemangiopericytoma / pathology*
  • Hemangiopericytoma / surgery
  • Humans
  • Immunoenzyme Techniques
  • Lipoma / chemistry
  • Lipoma / diagnostic imaging
  • Lipoma / pathology*
  • Lipoma / surgery
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / diagnostic imaging
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / surgery
  • Thigh / diagnostic imaging
  • Thigh / pathology
  • Thigh / surgery
  • Tomography, X-Ray Computed


  • Biomarkers, Tumor