The murine beta-chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4+ T cells

Eur J Immunol. 1999 Sep;29(9):2684-94. doi: 10.1002/(SICI)1521-4141(199909)29:09<2684::AID-IMMU2684>3.0.CO;2-Y.


To investigate specific properties of dendritic cells (DC) which are not shared by other antigen-presenting cells, we compared gene expression patterns of mouse DC and macrophages by differential mRNA display. One of the cDNA identified coded for a murine homolog of the human beta-chemokine, thymus and activation-regulated chemokine (TARC). The gene is expressed in a subset of bone marrow-derived DC and is up-regulated after lipopolysaccharide (LPS) stimulation. In vivo, murine TARC (mTARC) is constitutively expressed by thymic DC, lymphnode DC and CD11c+ cells in the lung. No expression was detected in bone marrow-derived macrophages and LPS-activated B cells. Recombinant mTARC has no chemoattractant activity on naive peripheral CD4+ T cells. In contrast, mTARC induced migration of primed ovalbumin-specific CD4+ T cells with a preference for Th2 cells during the early phase of the T cell response. These observations suggest that mTARC directs migration of antigen-experienced T helper cells to DC in lymphoid as well as in non-lymphoid organs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bone Marrow Cells / chemistry
  • Bone Marrow Cells / immunology
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Chemokine CCL17
  • Chemokines, CC / biosynthesis*
  • Chemokines, CC / genetics
  • Chemokines, CC / immunology
  • Cloning, Molecular
  • DNA, Complementary / isolation & purification
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Humans
  • Lymphocyte Activation
  • Macrophages / chemistry
  • Macrophages / immunology
  • Mice
  • Mice, Inbred C3H
  • Mice, Transgenic
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid


  • CCL17 protein, human
  • Ccl17 protein, mouse
  • Chemokine CCL17
  • Chemokines, CC
  • DNA, Complementary

Associated data

  • GENBANK/AJ242587