Estimating Kinetic Parameters From Dynamic Contrast-Enhanced T(1)-weighted MRI of a Diffusable Tracer: Standardized Quantities and Symbols

J Magn Reson Imaging. 1999 Sep;10(3):223-32. doi: 10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>3.0.co;2-s.

Abstract

We describe a standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast-enhanced T(1)-weighted magnetic resonance imaging data, using diffusable agents such as gadopentetate dimeglumine (Gd-DTPA). These include a) the volume transfer constant K(trans) (min(-1)); b) the volume of extravascular extracellular space (EES) per unit volume of tissue v(e) (0 < v(e) < 1); and c) the flux rate constant between EES and plasma k(ep) (min(-1)). The rate constant is the ratio of the transfer constant to the EES (k(ep) = K(trans)/v(e)). Under flow-limited conditions K(trans) equals the blood plasma flow per unit volume of tissue; under permeability-limited conditions K(trans) equals the permeability surface area product per unit volume of tissue. We relate these quantities to previously published work from our groups; our future publications will refer to these standardized terms, and we propose that these be adopted as international standards.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Contrast Media / pharmacokinetics*
  • Diffusion
  • Extracellular Space / metabolism
  • Gadolinium DTPA / pharmacokinetics*
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods*
  • Models, Biological
  • Terminology as Topic

Substances

  • Contrast Media
  • Gadolinium DTPA