Abstract
In the nematode Caenorhabditis elegans gonad shape and size is determined by the migration of a leader cell, which is at the tip of the growing gonad arm. A metalloprotease secreted by the leader cell has recently been found to play an essential role in this process, preparing the way ahead for the cell's migration.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADAM Proteins
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ADAMTS1 Protein
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Animals
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Basement Membrane
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Caenorhabditis elegans / enzymology*
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / growth & development
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Caenorhabditis elegans / physiology
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Caenorhabditis elegans Proteins*
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Cattle
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Cell Lineage
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Cell Movement / physiology*
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Disintegrins / genetics
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Disorders of Sex Development
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Embryonal Carcinoma Stem Cells
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Extracellular Matrix / physiology
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Extracellular Matrix Proteins / physiology*
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Genes, Reporter
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Gonads / cytology
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Gonads / growth & development
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Helminth Proteins / genetics
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Helminth Proteins / physiology*
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Larva
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Matrix Metalloproteinase 2 / physiology
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Metalloendopeptidases / genetics
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Metalloendopeptidases / physiology*
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Mice
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Models, Biological
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Morphogenesis / genetics
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Morphogenesis / physiology*
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Multigene Family
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Muscle Proteins / physiology
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Neoplasm Metastasis
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Neoplastic Stem Cells / cytology
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Peptide Fragments / genetics
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Procollagen / genetics
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Recombinant Fusion Proteins / physiology
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Species Specificity
Substances
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Caenorhabditis elegans Proteins
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Disintegrins
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Extracellular Matrix Proteins
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Helminth Proteins
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Muscle Proteins
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Peptide Fragments
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Procollagen
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Recombinant Fusion Proteins
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procollagen Type I N-terminal peptide
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ADAM Proteins
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ADAMTS1 Protein
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Adamts1 protein, mouse
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GON-1 protein, C elegans
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Metalloendopeptidases
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Matrix Metalloproteinase 2