Recombinant baculoviruses as expression vectors for insect and mammalian cells

Curr Opin Biotechnol. 1999 Oct;10(5):428-33. doi: 10.1016/s0958-1669(99)00005-1.


Baculovirus expression vectors are widely used for expressing heterologous proteins in cultured insect cells. Recent advances include further development of the system for production of multi-subunit protein complexes, co-expression of protein-modifying enzymes to improve heterologous protein production, and additional applications of baculovirus display technology. The application of modified baculovirus vectors for gene expression in mammalian cells continues to expand.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / genetics
  • Antigens / metabolism
  • Baculoviridae / genetics*
  • Gene Transfer Techniques
  • Genetic Vectors
  • Insecta / virology*
  • Mammals / virology*
  • Recombinant Proteins / genetics*
  • Recombinant Proteins / metabolism
  • Vaccines, Synthetic / genetics


  • Antigens
  • Recombinant Proteins
  • Vaccines, Synthetic