Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases

Curr Opin Cell Biol. 1999 Oct;11(5):591-6. doi: 10.1016/s0955-0674(99)00014-9.


Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion. IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and beta-catenin and induces the dissociation of alpha-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cadherins / physiology
  • Carrier Proteins / physiology
  • Cell Adhesion / physiology*
  • Cell Line
  • Cytoskeletal Proteins / physiology
  • Cytoskeleton / physiology
  • Dogs
  • Humans
  • Trans-Activators*
  • alpha Catenin
  • beta Catenin
  • cdc42 GTP-Binding Protein / physiology
  • rac1 GTP-Binding Protein / physiology
  • ras GTPase-Activating Proteins*
  • rho GTP-Binding Proteins / physiology*


  • CTNNA1 protein, human
  • CTNNB1 protein, human
  • Cadherins
  • Carrier Proteins
  • Cytoskeletal Proteins
  • IQ motif containing GTPase activating protein 1
  • Trans-Activators
  • alpha Catenin
  • beta Catenin
  • ras GTPase-Activating Proteins
  • cdc42 GTP-Binding Protein
  • rac1 GTP-Binding Protein
  • rho GTP-Binding Proteins