Mechanism of cell-cell adhesion complex assembly

Curr Opin Cell Biol. 1999 Oct;11(5):561-6. doi: 10.1016/s0955-0674(99)00021-6.

Abstract

Cell-cell adhesion complexes play an important role in the organization and behavior of cells in tissues. An important step in the formation of such complexes is the clustering of the adhesion receptors; this is critical for proper adhesion, for anchorage of the cytoskeleton to the plasma membrane, and for generation of different intracellular signals. Recent advances reveal that several interconnected mechanisms are responsible for clustering of the different adhesion receptors.

Publication types

  • Review

MeSH terms

  • Animals
  • Cadherins / chemistry
  • Cadherins / physiology
  • Calcium / physiology
  • Cell Adhesion / physiology*
  • Cell Adhesion Molecules / metabolism
  • Consensus Sequence
  • Desmosomes / physiology
  • Desmosomes / ultrastructure
  • Dimerization
  • Epithelial Cells / cytology*
  • Extracellular Matrix / physiology
  • Humans
  • Intercellular Junctions / physiology*
  • Intercellular Junctions / ultrastructure
  • Macromolecular Substances
  • Signal Transduction

Substances

  • Cadherins
  • Cell Adhesion Molecules
  • Macromolecular Substances
  • Calcium