Cadherins and their connections: adhesion junctions have broader functions

Curr Opin Cell Biol. 1999 Oct;11(5):554-60. doi: 10.1016/s0955-0674(99)00027-7.

Abstract

Cadherins - a family of cell-cell adhesion molecules - are linked to the actin cytoskeleton via intervening proteins. Recent results address molecular explanations for observed cadherin behavior, point to signals that regulate adhesion by modulating elements of the cadherin-associated complex, challenge the belief that different cadherins generally cannot cross-adhere, and highlight instructive roles for cadherins in cell signaling and differentiation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Binding Sites
  • Cadherins / chemistry
  • Cadherins / physiology*
  • Catenins
  • Cell Adhesion / physiology
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / physiology
  • Cell Differentiation
  • Cytoskeletal Proteins / metabolism
  • Cytoskeleton / metabolism
  • Desmoplakins
  • Humans
  • Intercellular Junctions / physiology*
  • Macromolecular Substances
  • Models, Biological
  • Phosphoproteins / chemistry
  • Phosphoproteins / physiology
  • Phosphorylation
  • Protein Binding
  • Protein Processing, Post-Translational
  • Protein Structure, Tertiary
  • Structure-Activity Relationship
  • Trans-Activators*
  • beta Catenin

Substances

  • Actins
  • CTNNB1 protein, human
  • Cadherins
  • Catenins
  • Cell Adhesion Molecules
  • Cytoskeletal Proteins
  • Desmoplakins
  • Macromolecular Substances
  • Phosphoproteins
  • Trans-Activators
  • beta Catenin
  • delta catenin