Metallo-beta-lactamase: Structure and Mechanism

Curr Opin Chem Biol. 1999 Oct;3(5):614-22. doi: 10.1016/s1367-5931(99)00017-4.


This past year has produced determinations of X-ray crystal structures for three metallo-beta-lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc enzyme. These advances shed light on how such a diverse group of enzymes are evolving to inactivate so efficiently a broad spectrum of beta-lactam antibiotics.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Catalysis
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Alignment
  • Structure-Activity Relationship
  • beta-Lactamases / chemistry
  • beta-Lactamases / metabolism*


  • beta-Lactamases