The nonribosomal code

Chem Biol. 1999 Oct;6(10):R273-9. doi: 10.1016/s1074-5521(00)80014-9.

Abstract

How genes are expressed and translated into proteins (using mRNA, codons and tRNAs as adaptor molecules) forms the basis of the 'genetic code'. Many peptides are synthesized nonribosomally, however, by large protein complexes that also serve as templates. Recent advances have shed light on what the nonribosomal code is and how it can be read.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acylation
  • Adenosine Monophosphate / metabolism
  • Animals
  • Humans
  • Peptide Biosynthesis / physiology*
  • Peptide Library
  • Sequence Alignment
  • Templates, Genetic

Substances

  • Peptide Library
  • Adenosine Monophosphate