Nuclear receptor cofactors as chromatin remodelers

Curr Opin Genet Dev. 1999 Oct;9(5):499-504. doi: 10.1016/s0959-437x(99)00010-6.


Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Chromatin / metabolism*
  • Histones / metabolism
  • Humans
  • Receptors, Cytoplasmic and Nuclear / metabolism*


  • Chromatin
  • Histones
  • Receptors, Cytoplasmic and Nuclear
  • Adenosine Triphosphate