Abstract
The establishment of a segmental pattern within the vertebrate body plan is achieved during embryogenesis by the somitogenesis process. Two molecular systems have been implicated in this phenomenon: a molecular clock linked to vertebrate segmentation and the Notch signalling pathway. Rhythmic expression of the Lunatic Fringe gene in the presomitic mesoderm has now provided a link between these two systems.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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Glycosyltransferases*
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Membrane Proteins / metabolism*
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Mesoderm / metabolism
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Mice
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Proteins / genetics
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Receptor Protein-Tyrosine Kinases / genetics
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Receptors, Notch
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Signal Transduction*
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Transcription Factors / genetics
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Xenopus
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Xenopus Proteins
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Membrane Proteins
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Mesp1 protein, mouse
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Mesp2 protein, mouse
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Proteins
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Receptors, Notch
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Transcription Factors
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Xenopus Proteins
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Glycosyltransferases
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LFNG protein, Xenopus
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Lfng protein, mouse
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Receptor Protein-Tyrosine Kinases