Notch around the clock

Curr Opin Genet Dev. 1999 Oct;9(5):559-65. doi: 10.1016/s0959-437x(99)00011-8.


The establishment of a segmental pattern within the vertebrate body plan is achieved during embryogenesis by the somitogenesis process. Two molecular systems have been implicated in this phenomenon: a molecular clock linked to vertebrate segmentation and the Notch signalling pathway. Rhythmic expression of the Lunatic Fringe gene in the presomitic mesoderm has now provided a link between these two systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Glycosyltransferases*
  • Membrane Proteins / metabolism*
  • Mesoderm / metabolism
  • Mice
  • Proteins / genetics
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptors, Notch
  • Signal Transduction*
  • Transcription Factors / genetics
  • Xenopus
  • Xenopus Proteins


  • Basic Helix-Loop-Helix Transcription Factors
  • Membrane Proteins
  • Mesp1 protein, mouse
  • Mesp2 protein, mouse
  • Proteins
  • Receptors, Notch
  • Transcription Factors
  • Xenopus Proteins
  • Glycosyltransferases
  • LFNG protein, Xenopus
  • Lfng protein, mouse
  • Receptor Protein-Tyrosine Kinases