Controls in Patterning and Diversification of Somatic Muscles During Drosophila Embryogenesis

Curr Opin Genet Dev. 1999 Oct;9(5):522-9. doi: 10.1016/s0959-437x(99)00014-3.


Recent genetic studies in Drosophila have provided important insights into the pathways determining the formation and diversification of body wall muscles. These pathways control a progressive subdivision of the mesoderm, ultimately leading to the specification of individual cells, the muscle founders, which are endowed with genetic programs capable of generating distinct muscle fibers. A network of activities of transcriptional regulators, signaling pathways, and lineage genes is beginning to emerge which controls successive steps of this muscle patterning and differentiation process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Patterning*
  • Cell Division
  • Drosophila / embryology*
  • Drosophila / genetics
  • Mesoderm
  • Muscles / embryology*