APC: the plot thickens

Curr Opin Genet Dev. 1999 Oct;9(5):595-603. doi: 10.1016/s0959-437x(99)00016-7.


Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyposis Coli / metabolism*
  • Adenomatous Polyposis Coli Protein
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / metabolism*
  • Drosophila / metabolism
  • Glycogen Synthase Kinase 3
  • Glycogen Synthase Kinases
  • Humans
  • Hydrolysis
  • Phosphorylation
  • Trans-Activators*
  • beta Catenin


  • Adenomatous Polyposis Coli Protein
  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • Trans-Activators
  • beta Catenin
  • Glycogen Synthase Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Glycogen Synthase Kinase 3