Lineages and transcription factors in the specification of vertebrate primary sensory neurons

D J Anderson

doi:10.1016/S0959-4388(99)00015-X

Lineages and transcription factors in the specification of vertebrate primary sensory neurons

Curr Opin Neurobiol. 1999 Oct;9(5):517-24. doi: 10.1016/S0959-4388(99)00015-X.

Author

D J Anderson¹

Affiliation

¹ Howard Hughes Medical Institute Division of Biology 216-76 California Institute of Technology Pasadena, California 91125, USA. barres@stanford.edu

PMID: 10508743
DOI: 10.1016/S0959-4388(99)00015-X

Abstract

Recent advances have indentified some of the key transcriptional regulators of mammalian genes, the neurogenins. Neurogenins 1 and 2 appear to control distinct sublineages for different classes of sensory neurons, including a 'pioneer' lineage for proprioceptors specified early in neural crest migration. Neurogenins act via a cascade of downstream transcriptional regulators, some of which have been identified.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Line / physiology
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / physiology
Neurons, Afferent / physiology*
Stem Cells / physiology
Transcription Factors / physiology*
Vertebrates / physiology*
Xenopus Proteins*

Substances

Basic Helix-Loop-Helix Transcription Factors
Nerve Tissue Proteins
Transcription Factors
Xenopus Proteins
neurogenin, Xenopus