Lineages and transcription factors in the specification of vertebrate primary sensory neurons

Curr Opin Neurobiol. 1999 Oct;9(5):517-24. doi: 10.1016/S0959-4388(99)00015-X.


Recent advances have indentified some of the key transcriptional regulators of mammalian genes, the neurogenins. Neurogenins 1 and 2 appear to control distinct sublineages for different classes of sensory neurons, including a 'pioneer' lineage for proprioceptors specified early in neural crest migration. Neurogenins act via a cascade of downstream transcriptional regulators, some of which have been identified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Line / physiology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology
  • Neurons, Afferent / physiology*
  • Stem Cells / physiology
  • Transcription Factors / physiology*
  • Vertebrates / physiology*
  • Xenopus Proteins*


  • Basic Helix-Loop-Helix Transcription Factors
  • Nerve Tissue Proteins
  • Transcription Factors
  • Xenopus Proteins
  • neurogenin, Xenopus