Conservation of neurogenic genes and mechanisms

Curr Opin Neurobiol. 1999 Oct;9(5):582-8. doi: 10.1016/S0959-4388(99)00017-3.


Reports from the past year have demonstrated that neural basic helix-loop-helix genes and LIM homeobox genes contribute to neuronal subtype specification in vertebrates and invertebrates, that Notch signaling specifies cell fates in the developing vertebrate inner ear, and that the organization of the central nervous system into three columns is shared by vertebrates and invertebrates. These findings pave the way for future work that will help to establish the extent to which these similarities represent evolutionary conservation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Conserved Sequence / physiology*
  • Genes, Homeobox / physiology
  • Helix-Loop-Helix Motifs / physiology
  • Membrane Proteins / physiology
  • Nervous System / embryology
  • Nervous System Physiological Phenomena*
  • Receptors, Notch
  • Signal Transduction / physiology


  • Membrane Proteins
  • Receptors, Notch