C-type lectin-like domains

Curr Opin Struct Biol. 1999 Oct;9(5):585-90. doi: 10.1016/s0959-440x(99)00009-3.


Carbohydrate-recognition domains of C-type (Ca2+-dependent) animal lectins serve as prototypes for an important family of protein modules. Only some domains in this family bind Ca2+ or sugars. A comparison of recent structures of C-type lectin-like domains reveals diversity in the modular fold, particularly in the region associated with Ca2+ and sugar binding. Some of this diversity reflects the changes that occur during normal physiological functioning of the domains. C-type lectin-like domains associate with each other through several different surfaces to form dimers and trimers, from which ligand-binding sites project in a variety of different orientations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Biological Evolution
  • Calcium / metabolism
  • Humans
  • Lectins / chemistry*
  • Lectins / metabolism*
  • Macromolecular Substances
  • Models, Molecular
  • Protein Conformation
  • Protein Folding


  • Lectins
  • Macromolecular Substances
  • Calcium