Association of familial deficiency of mannose-binding lectin and meningococcal disease

Lancet. 1999 Sep 25;354(9184):1094-5. doi: 10.1016/s0140-6736(99)02563-5.

Abstract

We report the case of an 18-year-old man with meningococcal meningitis and low serum concentrations of mannose-binding lectin (MBL). His mother and grandfather, who had also had meningitis in early adulthood, also had low concentrations of MBL in their serum.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adolescent
  • Carrier Proteins / blood*
  • Carrier Proteins / genetics*
  • Collectins
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Lectins / blood
  • Lectins / genetics
  • Male
  • Mannose / blood
  • Mannose / genetics
  • Meningitis, Meningococcal / blood
  • Meningitis, Meningococcal / genetics*
  • Neisseria meningitidis / isolation & purification*
  • Pedigree

Substances

  • Carrier Proteins
  • Collectins
  • Lectins
  • Mannose